538-543 Karmarkar LAJP 1720:Karmarkar
نویسندگان
چکیده
The present work deals with the comparison of in vitro dissolution profiles of fenofibrate liquisolid tablet formulations with those of marketed fenofibrate tablets, and the application of statistical methods to evaluate each method for its usefulness. The methods used to study dissolution profile comparison include Model independent method (Similarity factor, f2); Model dependent methods (Zero order, First order, Hixson-Crowell, Matrix, Peppas, Higuchi models) and statistical methods based on ANOVA. Model independent method was found to be easier and simple to interpret. The f2 value relates closeness of dissolution profiles. Dissolution profile followed Peppas model as “best fit” model. The application and evaluation of model dependent methods are more complicated. These methods give acceptable model approach which is indication of true relationship between percent drug release and time variables, including statistical assumptions. Statistical approach is very simple and is more discriminative of dissolution profiles. The liquisolid formulation of fenofibrate serves to be an effective way to enhance dissolution rate of fenofibrate.
منابع مشابه
219-225 Karmarkar LAJP 1626:Karmarkar
Fenofibrate is more effective drug as compared to other fibrates. But low bioavailability of it is due to its poor aqueous solubility. The purpose of present study was to improve fenofibrate dissolution through its formulation into liquisolid tablets and then to investigate in vitro performance of prepared liquisolid systems. By use of this technique, liquid medications such as solutions or sus...
متن کاملA gradient system on the quantum information space that realizes the Karmarkar flow for linear programming
Abstract. In the paper of Uwano [Czech. J. of Phys., vol.56, pp.1311-1316 (2006)], a gradient system is found on the space of density matrices endowed with the quantum SLD Fisher metric (to be referred to as the quantum information space) that realizes a generalization of a gradient system on the space of multinomial distributions studied by Nakamura [Japan J. Indust. Appl. Math., vol.10, pp.17...
متن کاملComputational Experience with an Interior Point Algorithm on the Satisfiability Problem
We apply the zero-one integer programming algorithm described in Karmarkar [12] and Karmarkar, Resende and Ramakrishnan [13] to solve randomly generated instances of the satisfiability problem (SAT). The interior point algorithm is briefly reviewed and shown to be easily adapted to solve large instances of SAT. Hundreds of instances of SAT (having from 100 to 1000 variables and 100 to 32,000 cl...
متن کاملA Unified Approach for Design of Lp Polynomial Algorithms
By summarizing Khachiyan's algorithm and Karmarkar's algorithm forlinear program (LP) a unified methodology for the design of polynomial-time algorithms for LP is presented in this paper. A key concept is the so-called extended binary search (EBS) algorithm introduced by the author. It is used as a unified model to analyze the complexities of the existing modem LP algorithms and possibly, help ...
متن کاملIntracoronary MR Imaging Using a Novel 0.014-inch MRIG: Toward MRI-Guided Coronary Interventions
B. Qiu, F. Gao, T. K. Foo, P. Karmarkar, E. Atalar, and X. Yang Radiology, Image-guided bio-molecular intervention section, University of Washington Medical Center, Seattle, WA, United States, Radiology, Johns Hopkins University, Baltimore, MD, United States, Applied Science Laboratory, GE Healthcare, Baltimore, MD, United States, Electrical and Electronics Engineering, Bilkent University, Anka...
متن کامل